Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa

被引：51

作者：

Edgeworth, Jonathan D. ^{[1
]}

Merante, Domenico ^{[2
]}

Patel, Sanjay ^{[2
,3
]}

Young, Christopher ^{[3
]}

Jones, Paul ^{[4
]}

Vithlani, Seema ^{[5
]}

Wyncoll, Duncan ^{[3
]}

Roberts, Peter ^{[3
]}

Jones, Andrew ^{[3
]}

Den Nagata, Tsutae ^{[6
]}

Ariyasu, Mari ^{[6
]}

Livermore, David M. ^{[7
,8
]}

Beale, Richard ^{[9
]}

机构：

[1] Kings Coll London, Guys Hosp, Dept Infect Dis, London, England

[2] Shionogi Ltd, Global Clin Dev Unit, London, England

[3] HCA Int, Intens Care Unit, London Bridge Hosp, London, England

[4] HCA Int, Microbiol Dept, London, England

[5] HCA Int, Pharm Dept, London Bridge Hosp, London, England

[6] Shionogi & Co Ltd, Kita Ku, Osaka, Japan

[7] Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England

[8] Publ Hlth England, Antimicrobial Resistance & Healthcare Associated, London, England

[9] Kings Coll London, Sch Med, Guys Hosp, London, England

来源：

CLINICAL INFECTIOUS DISEASES | 2019年 / 68卷 / 11期

关键词：

cefiderocol; endocarditis; Pseudomonas aeruginosa; drug resistance; microbial; SIDEROPHORE CEPHALOSPORIN;

D O I：

10.1093/cid/ciy963

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Serious infections such as endocarditis due to extremely drug-resistance gram-negative bacteria are an increasing challenge. Here, we present successful adjunctive use of cefiderocol for a patient with persistently bacteremic healthcare-associated native aortic valve endocarditis due to an extended-spectrum beta-lactamase-positive Pseudomonas aeruginosa susceptible in vitro only to colistin, following failure of conventional therapeutic options.

引用

页码：1932 / 1934

页数：3

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