Epidemiology and outcomes of elderly patients requiring renal replacement therapy in the intensive care unit: an observational study

被引:5
|
作者
Salathe, Cecile [1 ,2 ]
Poli, Elettra [1 ]
Altarelli, Marco [1 ]
Bianchi, Nathan Axel [1 ]
Schneider, Antoine Guillaume [1 ,3 ]
机构
[1] Ctr Hosp Univ Vaudois CHUV, Adult Intens Care Unit, Serv Med Intens Adulte, 46 Ave Bugnon, CH-1011 Lausanne, Switzerland
[2] Reseau Hosp Neuchatelois RHNE, Intens Care Unit, Neuchatel, Switzerland
[3] Univ Lausanne, Fac Biol & Med, Lausanne, Switzerland
关键词
Renal replacement therapy (RRT); Acute kidney injury (AKI); Elderly; Mortality; Quality of life (QOL);
D O I
10.1186/s12882-021-02302-4
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
BackgroundRenal replacement therapy (RRT) in critically ill patients is associated with high morbidity and mortality. The appropriateness of RRT initiation is sometimes questioned in elderly patients. Therefore, we sought to evaluate the long-term mortality, dialysis dependence and quality of life (QOL) of elderly patients who survived critical illness requiring RRT.MethodsThis is a monocentric observational study including all patients >55 yo who received RRT for acute kidney injury in our intensive care unit (ICU) between January 2015 and April 2018. At the time of the study (May 2019), we assessed if they were still alive by cross referencing our hospital database and the Swiss national death registry. We sent survivors written information and, subsequently, contacted them over the phone. We obtained their consent for participation, asked about their dialytic status and performed an EQ-5D survey with visual analog scale (VAS). Results were stratified according to their age at the time of ICU admission (G1: "55-65 yo"; G2: ">65-75 yo" and G3: ">75 yo"). QOL in G3 patients were compared to G1 and G2 and to predicted values.ResultsAmong the 352 eligible patients, 171 died during the index hospital admission. After a median follow-up time of 32.7months (IQR 19.8), a further 62 had died (median time to death for ICU survivors 5.0 (IQR 15.0) months. Hence, 119 (33.6%) patients were still alive at the time of the study. We successfully contacted 96 (80.7%) of them and 83 (69.7%) were included in the study (G1: 24, G2: 44 and G3: 15). Only 6 (7.2%) were RRT dependent. Patients in G3 had lower EQ-5D and VAS scores than those in G1 and G2 (p <0.01). These scores were also significantly lower than predicted values (p <0.05).ConclusionsRRT patients have a very high in-hospital and post discharge mortality. Among survivors, RRT dependency was low. Irrespective of baseline values, patients >75 yo who survived ICU had a lower QOL than younger patients. It was lower than predicted according to age and sex. The appropriateness of RRT initiation in elderly patients should be discussed according to their pre-existing QOL and frailty.
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页数:8
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