In Vitro Characteristics of Heparin/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Nanocomplexes

被引：2
|
作者：
Kim, Yu-Jeong
Chae, Su Young [2 ]
Jin, Cheng-Hao [2 ]
Park, Jae Hyung [1 ,3 ]
Lee, Kang Choon [2 ]
机构：
[1] Kyung Hee Univ, Coll Environm & Appl Chem, Dept Adv Polymer & Fiber Mat, Gyeonggi Do 449701, South Korea
[2] Sungkyunkwan Univ, Coll Pharm, Gyeonggi Do, South Korea
[3] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul, South Korea
来源：
MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 2009年 / 508卷
关键词：
heparin; nano-complex; protein stability; TRAIL; CANCER; INDUCTION; STABILITY;
D O I：
10.1080/15421400903058825
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In an attempt to improve the stability of tumor necrosis factor-related apoptosis inducing ligand ( TRAIL), we prepared the nano-sized complexes by mixing the positively charged TRAIL with heparin, a highly sulfated polysaccharide. The increase in the feed ratio (FR) of heparin to TRAIL reduced the particle size and decreased the zeta-potential, indicating that the TRAIL surface was covered by heparin via the ionic interactions. TRAIL in the complexes was demonstrated to effectively induce apoptosis of the cancer cells. The results indicated that heparin is the useful, anionic polysaccharide as the carrier of TRAIL to form stable nano-sized complexes.
引用
收藏
页码：91 / 100
页数：10
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