Content of Steroid Hormones in the Blood and Adrenal Glands of Mice in the Dynamics of BCG- and SiO2-Induced Granulomatous Inflammation

被引:1
|
作者
Palchikova, N. A. [1 ]
Kuzminova, O. I. [1 ]
Utkina, N. V. [1 ]
Selyatitskaya, V. G. [1 ]
Shkurupiy, V. A. [1 ]
机构
[1] Russian Acad Med Sci, Res Ctr Clin & Expt Med, Siberian Div, Novosibirsk, Russia
关键词
chronic granulomatous inflammation; BCG vaccine; silicon dioxide; corticosteroids; testosterone;
D O I
10.1007/s10517-009-0396-3
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Individual or combined administration of BCG vaccine and silicon dioxide to male mice induced a nonspecific stress response of the adrenal glands and gonads judging from changes in the concentration of blood cortisol and testosterone. The dynamics of cortisol concentration in the adrenal glands was similar, while changes in progesterone concentration were in antiphase to those in the blood. After combined administration of both inductors of granulomatous inflammation, changes in the concentrations of the studied hormones to a greater extent corresponded to their dynamics after injection of BCG.
引用
收藏
页码:705 / 707
页数:3
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