Ethanol-induced c-Fos expression in rat lines selected for low and high alcohol consumption

被引：51

作者：

Thiele, TE

vanDijk, G

Bernstein, IL

机构：

[1] Department of Psychology, University of Washington, Box 351525, Seattle

来源：

BRAIN RESEARCH | 1997年 / 756卷 / 1-2期

关键词：

ethanol; c-Fos; genetics; selected line; locus coeruleus; nucleus accumbens;

D O I：

10.1016/S0006-8993(97)00228-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Selectively bred rat lines, developed to model genetic contributions to alcohol abuse, include the Indiana alcohol-preferring (P) and alcohol-nonpreferring (NP) Lines, and the Alko-Alcohol (AA) and Alko-Nonalcohol (ANA) lines. Preferring and nonpreferring lines were compared in their response to intraperitoneal injection of either ethanol or isotonic saline using c-Fos expression as a marker of neuronal activity. Although line differences were noted in several brain regions, the principal finding was that alcohol-nonpreferring lines (NP and ANA) displayed greater c-Fos expression in the locus coeruleus (LC) relative to the alcohol-preferring lines (P and AA) following injection of 3.0 g ethanol/kg. These data point to the LC as an area which may play a role in the differences in voluntary ethanol consumption between rat lines genetically bred for low and high ethanol preference.

引用

页码：278 / 282

页数：5

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