Preparation, structure and drug release behaviour of chitosan-based nanofibres

被引:10
|
作者
Zeng, R. [1 ,2 ]
Tu, M. [1 ,2 ]
Liu, H. -W. [1 ]
Zhao, J. -H. [1 ,2 ]
Zha, Z. -G. [2 ,3 ]
Zhou, C. -R. [1 ,2 ]
机构
[1] Jinan Univ, Coll Sci & Engn, Dept Mat Sci & Engn, Guangzhou 510632, Peoples R China
[2] Minist Educ, Engn Res Ctr Artificial Organs & Mat, Guangzhou 510632, Peoples R China
[3] Jinan Univ, Affiliated Hosp 1, Guangzhou Overseas Chinese Hosp, Guangzhou 510630, Peoples R China
基金
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词
TISSUE; DELIVERY;
D O I
10.1049/iet-nbt:20080010
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Biomimetic polymeric nanofibres are of great interest in tissue engineering and wound repair because of their structural similarity to extracellular matrix. In this work, biomimetic chitosan-based nanofibres with various diameters were prepared by ionically cross-linking with tripolyphosphate (TPP) in adipic acid medium and characterised using transmission electron microscopy, X-ray diffraction and Fourier-transform infrared spectroscopy. Using dexamethasone sodium phosphate (DMP) and bovine serum albumin (BSA) as low and high molecular-weight bioactive molecule models, respectively, drug loading and in vitro release behaviours of chitosan-TPP nanofibres were investigated. The drug-loaded chitosan-TPP nanofibres showed a prolonged release pro. le with three distinct stages in physiological conditions because of the complicated release mechanisms involving diffusion of the drug and degradation of the nanofibre, and BSA-loaded nanofibres showed a smaller release rate than DMP-loaded nanofibres. It is proposed that biomimetic chitosan-based nanofibres may be of use in tissue engineering for sustained release of bioactive agents.
引用
收藏
页码:8 / 13
页数:6
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