Development of enzymatically cleavable prodrugs derived from dendritic polyglycerol

被引：93
|
作者：
Calderon, Marcelo [2 ]
Graeser, Ralph [3 ]
Kratz, Felix [1 ]
Haag, Rainer [2 ]
机构：
[1] Tumor Biol Ctr, D-79106 Freiburg, Germany
[2] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany
[3] Proquinase, D-79106 Freiburg, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 14期
关键词：
Polyglycerol; Polymer therapeutics; Prodrug; Doxorubicin; Methotrexate; Drug conjugate; Controlled release; Nanocarrier; DESIGNING DENDRIMERS; DRUG-DELIVERY; THERAPEUTICS; METHOTREXATE; ALBUMIN;
D O I：
10.1016/j.bmcl.2009.05.058
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this Letter we report the synthesis and in vitro studies of cleavable polymer-drug conjugates derived from dendritic polyglycerol and maleimide-bearing prodrugs of doxorubicin and methotrexate that are cleaved by cathepsin B. Cleavage properties and cytotoxicity of the new conjugates are presented. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3725 / 3728
页数：4
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