Molecular imaging to track Parkinson's disease and atypical parkinsonisms: New imaging frontiers

被引：77

作者：

Strafella, Antonio P. ^{[1
,2
,3
,4
]}

Bohnen, Nicolaas I. ^{[5
,6
]}

Perlmutter, Joel S. ^{[7
]}

Eidelberg, David ^{[8
]}

Pavese, Nicola ^{[9
,10
]}

Van Eimeren, Thilo ^{[11
]}

Piccini, Paola ^{[12
]}

Politis, Marios ^{[13
]}

Thobois, Stephane ^{[14
,15
]}

Ceravolo, Roberto ^{[16
]}

Higuchi, Makoto ^{[17
]}

Kaasinen, Valtteri ^{[18
,19
,20
]}

Masellis, Mario ^{[21
,22
]}

Peralta, M. Cecilia ^{[23
]}

Obeso, Ignacio ^{[24
,25
]}

Pineda-Pardo, Jose Angel ^{[24
,25
]}

Cilia, Roberto ^{[26
]}

Ballanger, Benedicte ^{[27
,28
,29
]}

Niethammer, Martin ^{[8
]}

Stoessl, Jon A. ^{[30
,31
,32
]}

机构：

[1] UHN, Toronto Western Hosp, Morton & Gloria Shulman Movement Disorder Unit, Neurol Div,Dept Med, Toronto, ON, Canada

[2] UHN, Toronto Western Hosp, EJ Safra Parkinson Dis Program, Neurol Div,Dept Med, Toronto, ON, Canada

[3] UHN, Krembil Res Inst, Toronto, ON, Canada

[4] Univ Toronto, CAMH, Campbell Family Mental Hlth Res Inst, Res Imaging Ctr, Toronto, ON, Canada

[5] Univ Michigan, Ann Arbor, MI 48109 USA

[6] Vet Adm Med Ctr, Ann Arbor, MI 48105 USA

[7] Washington Univ, Neurol Radiol Neurosci Phys Therapy & Occupat The, St Louis, MO USA

[8] Feinstein Inst Med Res, Ctr Neurosci, Manhasset, NY USA

[9] Newcastle Univ, Newcastle Magnet Resonance Ctr, Campus Ageing & Vitality, Newcastle Upon Tyne, Tyne & Wear, England

[10] Newcastle Univ, Positron Emiss Tomog Ctr, Campus Ageing & Vitality, Newcastle Upon Tyne, Tyne & Wear, England

[11] Univ Cologne, German Ctr Neurodegenerat Dis DZNE, Inst Neurosci & Med,Julich Res Ctr, Multimodal Neuroimaging Grp,Dept Nucl Med,Dept Ne, Cologne, Germany

[12] Imperial Coll London, Div Brain Sci, Ctr Neuroinflammat & Neurodegenerat, Neurol Imaging Unit, Hammersmith Campus, London, England

[13] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Basic & Clin Neurosci, Neurodegenerat Imaging Grp, London, England

[14] Univ Lyon 1, Hop Neurol Pierre Wertheimer, Hosp Civils Lyon, Lyon, France

[15] CNRS, Ctr Neurosci Cognit, UMR 5229, Lyon, France

[16] Univ Pisa, Dept Clin & Expt Med, Movement Disorders & Parkinson Ctr, Pisa, Italy

[17] Natl Inst Quantum & Radiol Sci & Technol, Natl Inst Radiol Sci, Chiba, Japan

[18] Turku Univ Hosp, Div Clin Neurosci, Turku, Finland

[19] Univ Turku, Dept Neurol, Turku, Finland

[20] Univ Turku, Turku PET Ctr, Turku, Finland

[21] Univ Toronto, Sunnybrook Hlth Sci Ctr, Cognit & Movement Disorders Clin, Toronto, ON, Canada

[22] Univ Toronto, Hurvitz Brain Sci Res Program, Sunnybrook Res Inst, Toronto, ON, Canada

[23] CEMIC Univ Hosp, Movement Disorder & Parkinsons Dis Program, Buenos Aires, DF, Argentina

[24] Hosp Madrid Puerta Sur, Ctr Integral Neurociencias CINAC, Madrid, Spain

[25] Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain

[26] ASST Gaetano Pini CTO, Parkinson Inst, Milan, Italy

[27] INSERM, U1028, Lyon, France

[28] CNRS, UMR5292, Lyon, France

[29] Lyon Neurosci Res Ctr, Neuroplast & Neuropathol Olfactory Percept Team, Lyon, France

[30] Univ British Columbia, Pacific Parkinsons Res Ctr, Vancouver, BC, Canada

[31] Univ British Columbia, Natl Parkinson Fdn Ctr Excellence, Vancouver, BC, Canada

[32] Vancouver Coastal Hlth, Vancouver, BC, Canada

来源：

MOVEMENT DISORDERS | 2017年 / 32卷 / 02期

关键词：

Parkinson's disease; atypical parkinsonism; PET; dopamine; serotonin; acetylcholine; amyloid; tau; FDG; POSITRON-EMISSION-TOMOGRAPHY; PROGRESSIVE SUPRANUCLEAR PALSY; METABOLIC BRAIN NETWORKS; STRIATAL DOPAMINE RELEASE; IMPULSE CONTROL DISORDERS; MICROGLIAL ACTIVATION; NIGROSTRIATAL DYSFUNCTION; COGNITIVE IMPAIRMENT; SUBTHALAMIC NUCLEUS; WITHDRAWAL SYNDROME;

D O I：

10.1002/mds.26907

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Molecular imaging has proven to be a powerful tool for investigation of parkinsonian disorders. One current challenge is to identify biomarkers of early changes that may predict the clinical trajectory of parkinsonian disorders. Exciting new tracer developments hold the potential for in vivo markers of underlying pathology. Herein, we provide an overview of molecular imaging advances and how these approaches help us to understand PD and atypical parkinsonisms. (c) 2016 International Parkinson and Movement Disorder Society.

引用

页码：181 / 192

页数：12

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