Human Embryonic Stem Cell-Derived Cardiomyocytes A Nonviable Therapeutic Approach

被引：5
|
作者：
Bolli, Roberto [1 ]
Wysoczynski, Marcin [1 ]
机构：
[1] Univ Louisville, Inst Mol Cardiol, Louisville, KY 40292 USA
来源：
CIRCULATION RESEARCH | 2019年 / 124卷 / 08期
关键词：
Editorials; animals; humans; monocytes; cardiac; primates; CARDIAC MYOCYTES; METAANALYSIS;
D O I：
10.1161/CIRCRESAHA.119.314869
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In 2014, Chong et al1 published an article claiming that human embryonic stem cell-derived cardiomyocytes (hESC-CMs) remuscularize nonhuman primate hearts. Those conclusions, however, were not supported by the data; in addition, there were numerous other methodological issues, as detailed by Anderson et al. 2 Now, the same group has published an article claiming that hESC-CMs restore function in the hearts of nonhuman primates and that this effect is durable. 3 Unfortunately, this report is also problematic in that it does not provide sufficient evidence to support the main conclusions of the study, and the clinical relevance of the observation is unclear.
引用
收藏
页码：1157 / 1159
页数：3
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