Efficient syntheses of a series of glycosphingolipids with 1,2-trans-glycosidic linkages

被引：15

作者：

Liu, Yunpeng ^{[1
]}

Ding, Ning ^{[1
]}

Xiao, Hualing ^{[1
]}

Li, Yingxia ^{[1
]}

机构：

[1] Ocean Univ China, Sch Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 2006年 / 25卷 / 06期

关键词：

glycosphingolipid with 1,2-trans-glycosidic linkage; Schmidt's; glycosyl trichloroacetimidate; Azido-sphingosine; glycosylation; conformation;

D O I：

10.1080/07328300600859825

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of glycosphingolipids with 1,2-trans-glycosidic linkages were synthesized in the presence of neighboring group participation using trichloroacetimidates as glycosyl donors and an azido-sphingosine as the glycosyl acceptor. During the preparation of the target compounds, it was found that the alpha-L-arabinopyranosyl unit in target 7e and intermediates 7b - 7d existed in the C-1(4) conformation and that the b-L-fucopyranosyl unit in 10e adopted the C-4(1) conformation.

引用

页码：471 / 489

页数：19

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