Hypoxia-responsive nanomaterials for tumor imaging and therapy

被引：4
|
作者：
Xia, Yifei [1 ]
Duan, Shao [1 ]
Han, Chaozhe [1 ]
Jing, Chengwei [1 ]
Xiao, Zunyu [2 ]
Li, Chao [1 ]
机构：
[1] Harbin Med Univ, Dept Orthoped, Affiliated Hosp 2, Harbin, Peoples R China
[2] Harbin Med Univ, Dept Nucl Med, Hosp 4, Harbin, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
关键词：
stimuli-responsive nanoparticle; hypoxia tumor microenvironment; drug delivery; cancer imaging; tumor microenvironment targeted theranostics; IRON-OXIDE NANOPARTICLES; UP-CONVERSION NANOPARTICLES; PHOTODYNAMIC THERAPY; PHOTOTHERMAL THERAPY; DELIVERY-SYSTEM; CANCER; MACROPHAGES; GROWTH; CELLS; AQ4N;
D O I：
10.3389/fonc.2022.1089446
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hypoxia is an important component of tumor microenvironment and plays a pivotal role in cancer progression. With the distinctive physiochemical properties and biological effects, various nanoparticles targeting hypoxia had raised great interest in cancer imaging, drug delivery, and gene therapy during the last decade. In the current review, we provided a comprehensive view on the latest progress of novel stimuli-responsive nanomaterials targeting hypoxia-tumor microenvironment (TME), and their applications in cancer diagnosis and therapy. Future prospect and challenges of nanomaterials are also discussed.
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页数：15
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