Methylmercury induces caspase-dependent apoptosis and autophagy in human neural stem cells

被引：1
|
作者：
Chang, Seung-Hee [1 ]
Lee, Hong Jun [2 ]
Kang, Bitna [1 ]
Yu, Kyeong-Nam [1 ]
Minai-Tehrani, Arash [1 ]
Lee, Somin [1 ,3 ]
Kim, Seung U. [2 ,4 ]
Cho, Myung-Haing [1 ,3 ,5 ,6 ]
机构：
[1] Seoul Natl Univ, Coll Vet Med, Toxicol Lab, Seoul 151742, South Korea
[2] Chung Ang Univ, Coll Med, Med Res Inst, Seoul 156756, South Korea
[3] Seoul Natl Univ, Grad Grp Tumor Biol, Seoul 110799, South Korea
[4] Univ British Columbia, Dept Med, Div Neurol, Vancouver, BC V6T 2B5, Canada
[5] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Seoul 151742, South Korea
[6] Seoul Natl Univ, Adv Inst Convergence Technol, Suwon 443270, South Korea
来源：
JOURNAL OF TOXICOLOGICAL SCIENCES | 2013年 / 38卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
Methylmercury (MeHg); Human neural stem cell (NSC); Apoptosis; Autophagy; OXIDATIVE STRESS; DEATH; ACTIN; NEUROTOXICITY; NECROSIS; POLARITY; MERCURY; SIGNALS; BRAIN; CYTOSKELETON;
D O I：
暂无
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Methylmercury (MeHg) is a well-known human neurotoxic agent whose exposure sources are mainly environmental and aquatic-derived food. MeHg is reported to induce central nervous system disability. However, the exact mechanism of MeHg-induced neurotoxicity is still unknown. In this study, to investigate which cell death signaling pathway is related with MeHg-induced cytotoxicity, the effects of MeHg on apoptosis and autophagy were evaluated in HB1.F3 human neural stem cells (NSCs). Human NSCs were treated with 1 mu M of MeHg for 48 hr and the effect of MeHg on cell signaling pathway was elucidated. MeHg inhibited Akt1/mTOR signaling that led to induction of caspase-dependent apoptosis and autophagy in the NSCs. Furthermore, retinoic acid (RA)-induced neuronal differentiation was inhibited by MeHg. Taken together, these results suggest that MeHg inhibits the differentiation of human NSCs by induction of caspase-dependent apoptosis and autophagy.
引用
收藏
页码：823 / 831
页数：9
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