Role of abdominal obesity in pathogenesis of insulin-resistance syndrome

Aim. To study relationships between pathogenesis of obesity, essential hypertension (EH), hyperlipidemia, ischemic heart disease (IHD) and diabetes mellitus (DM) type II. Materials and methods. Glucose and insulin levels in blood, serum lipids were measured, glucose and prednisolone glucose tolerance tests were made in 75 patients with abdominal and 75 patients with gluteofemoral obesity. Results. The results of the study of 75, 75, 763 and 340 patients with abdominal, gluteofemoral obesity, IHD and DM type II, respectively, show that pathogenesis of abdominal obesity, essential hypertension, hyperlipidemia, IHD, abnormal glucose tolerance and diabetes mellitus type II has common features: relative hypercorticoidism, insulin resistance and hyperinsulinemia. Conclusion. Abdominal obesity is the earliest symptom in composition of metabolic cardiovascular syndrome. Prevention or early treatment of this obesity can prevent or delay onset of diseases associated with this syndrome.