HLA allele and haplotype frequencies in the Panamanian population

被引：3

作者：

Llanes, Alejandro ^{[1
]}

Ortiz, Luis ^{[2
]}

Moscoso, Juan ^{[2
]}

Gutierrez, Gina ^{[2
]}

Blake, Elena ^{[2
]}

Restrepo, Carlos M. ^{[1
]}

Lleonart, Ricardo ^{[1
]}

Cuero, Cesar ^{[3
]}

Vernaza-Kwiers, Alejandro ^{[2
]}

机构：

[1] Inst Invest Cient & Serv Alta Tecnol INDICASAT AI, Ctr Biol Celular & Mol Enfermedades, Panama City, Panama

[2] Complejo Hosp Dr Arnulfo Arias Madrid CHDrAAM, Lab Nacl Trasplante, Panama City, Panama

[3] Complejo Hosp Dr Arnulfo Arias Madrid CHDrAAM, Serv Nefrol, Panama City, Panama

来源：

HUMAN IMMUNOLOGY | 2021年 / 82卷 / 01期

关键词：

HLA genotyping; Allele frequencies; Haplotype frequencies; Panama; Hispanic population;

D O I：

10.1016/j.humimm.2020.11.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we report for the first time HLA allele and haplotype frequencies in the modern Panamanian population at a two-field (four digits) resolution level. Reported frequencies were calculated from genotype data for the HLA-A,-B,-C,-DPB1,-DQB1 and-DRB1 loci of 462 healthy unrelated Panamanian adults of Hispanic ethnicity. In addition to providing new insights on the allelic structure of the Panamanian population and its origin, these data are critical for better planning of healthcare strategies in the country and for future research exploring the association with certain chronic and infectious diseases. (C) 2020 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：5 / 7

页数：3

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