From erythropoietin to oxygen: Hypoxia-inducible factor hydroxylases and the hypoxia signal pathway

被引：44
|
作者：
Ratcliffe, PJ [1 ]
机构：
[1] Univ Oxford, Renal & Cell Physiol Grp, Oxford OX3 7BN, England
来源：
BLOOD PURIFICATION | 2002年 / 20卷 / 05期
关键词：
erythropoietin; hypoxia-inducible factor; prolyl hydroxylase; oxygen sensing;
D O I：
10.1159/000065201
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The regulation of blood red cell production by the hormone erythropoietin (Epo) provides a paradigm for control of gene expression by oxygen. Analysis of this pathway has revealed a widespread system of gene regulation based on a transcriptional complex termed hypoxia-inducible factor (HIF). Hydroxylation of specific prolyl and asparinyl residues in the a subunit of HIF by a series of non-haem iron-dependent dioxygenases has been defined as a novel mechanism of protein modification that transduces the oxygen-sensitive signal. Copyright (C) 2002 S. Karger AG, Basel.
引用
收藏
页码：445 / 450
页数：6
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