Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis

被引：37
|
作者：
Xu, Xin [1 ,2 ]
Lu, Linlin [2 ,3 ]
Dong, Quanyong [1 ,2 ]
Li, Xiaolin [1 ,2 ]
Zhang, Nannan [1 ,2 ]
Xin, Yongning [1 ,2 ,3 ]
Xuan, Shiying [1 ,2 ,3 ]
机构：
[1] Dalian Med Univ, Qingdao Municipal Hosp, Dept Gastroenterol, Qingdao, Peoples R China
[2] Digest Dis Key Lab Qingdao, Qingdao, Peoples R China
[3] Qingdao Municipal Hosp, Cent Labs, Qingdao, Peoples R China
来源：
LIPIDS IN HEALTH AND DISEASE | 2015年 / 14卷
关键词：
Nonalcoholic fatty liver disease; Atherosclerosis; Insulin resistance; Metabolic syndrome; Cardiovascular disease; CORONARY-ARTERY-DISEASE; OBSTRUCTIVE SLEEP-APNEA; INTIMA-MEDIA THICKNESS; NF-KAPPA-B; TYPE-2; DIABETIC-PATIENTS; EPICARDIAL ADIPOSE-TISSUE; CHRONIC KIDNEY-DISEASE; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; CAROTID ATHEROSCLEROSIS;
D O I：
10.1186/s12944-015-0141-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver disease that is closely related not only to genetic susceptibility but also to insulin resistance and highly linked with metabolic syndrome. In recent years, the prevalence of NAFLD has increased rapidly, paralleling the epidemic of type 2 diabetes mellitus and obesity leading to cardiovascular disease. It has been demonstrated that NAFLD is highly associated with atherosclerosis. With recently gained knowledge, it appears that NAFLD may induce insulin resistance, dyslipidemia, oxidative stress, inflammation, and fluctuation of adipokines associated with atherosclerosis. In this review, we aimed to summarize recent discoveries related to both NAFLD and atherosclerosis, and to identify possible mechanisms linking them.
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页数：8
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