The Swi/Snf chromatin remodeling complex is required for ribosomal DNA and telomeric silencing in Saccharomyces cerevisiae

被引：41
|
作者：
Dror, V
Winston, F
机构：
[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
[2] Tel Aviv Univ, Dept Biochem, IL-69978 Tel Aviv, Israel
来源：
MOLECULAR AND CELLULAR BIOLOGY | 2004年 / 24卷 / 18期
关键词：
D O I：
10.1128/MCB.24.18.8227-8235.2004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Swi/Snf chromatin remodeling complex has been previously demonstrated to be required for transcriptional activation and repression of a subset of genes in Saccharomyces cerevisiae. In this work we demonstrate that Swi/Snf is also required for repression of RNA polymerase II-dependent transcription in the ribosomal DNA (rDNA) locus (rDNA silencing). This repression appears to be independent of both Sir2 and Set1, two factors known to be required for rDNA silencing. In contrast to many other rDNA silencing mutants that have elevated levels of rDNA recombination, snf2Delta mutants have a significantly decreased level of rDNA recombination. Additional studies have demonstrated that Swi/Snf is also required for silencing of genes near telomeres while having no detectable effect on silencing of HML or HMR.
引用
收藏
页码：8227 / 8235
页数：9
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