Accurate prediction of DNA opening profiles by Peyrard-Bishop nonlinear dynamic simulations

被引：0
|
作者：
Choi, C. H. [1 ]
Kalosakas, G. [1 ]
Rasmussen, K. O. [1 ]
Bishop, A. R. [1 ]
Usheva, A. [1 ]
机构：
[1] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
来源：
PROCEEDINGS OF THE FOURTH INTERNATIONAL CONFERENCE ON BIOINFORMATICS OF GENOME REGULATION AND STRUCTURE, VOL 1 | 2004年
关键词：
physical properties of DXA; thermal opening profiles; DNA dynamics; S1; nuclease;
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Motivation: The Peyrard-Bishop nonlinear model has proven to be an accurate predictor of the elastic properties of DNA.,Through dynamical simulations, it is possible to gather statistical data on the local opening propensity of a limited sequence of double-stranded DNA. It is important to compare these computational results with experiment, to evaluate the usefulness of the Peyrard-Bishop model in a predictive capacity. Results: Simulation and analysis of three linear DNA duplexes yields three distinct opening profiles by the Peyrard-Bishop model. Controlled digestion of radioactively-labeled templates by S1 nuclease, which selectively cleaves. single-stranded DNA, shows an excellent correlation of the predicted openings with experimental data.
引用
收藏
页码：46 / 49
页数：4
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