The development of brain magnetic resonance approaches in large animal models for preclinical research

被引：10

作者：

Ella, Arsene ^{[1
,2
]}

Barriere, David A. ^{[1
,3
]}

Adriaensen, Hans ^{[1
]}

Palmer, David N. ^{[4
]}

Melzer, Tracy R. ^{[5
,6
]}

Mitchell, Nadia L. ^{[4
,7
]}

Keller, Matthieu ^{[1
]}

机构：

[1] Univ Tours, Physiol Reprod & Comportements, INRA, CNRS, Tours, France

[2] Univ Cambridge, MRC Cognit & Brain Sci Unit, Cambridge, England

[3] CEA, Neurospin, Gif Sur Yvette, France

[4] Lincoln Univ, Fac Agr & Life Sci, Lincoln, New Zealand

[5] Univ Otago, Dept Med, Christchurch, New Zealand

[6] New Zealand Brain Res Inst, Christchurch, New Zealand

[7] Univ Otago, Dept Radiol, Christchurch, New Zealand

来源：

ANIMAL FRONTIERS | 2019年 / 9卷 / 03期

关键词：

brain; image analysis; magnetic resonance imaging; pathology; NEURONAL CEROID-LIPOFUSCINOSIS; SOUTH HAMPSHIRE SHEEP; ATLAS;

D O I：

10.1093/af/vfz024

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

• Magnetic resonance imaging is a very powerful approach to perform anatomical and functional imaging explorations. • Large animal models are perfectly suited for MRI studies using clinical devices and these tools are currently being developed and improved. • Here we highlight an example of MRI to demonstrate the efficacy of gene therapy in sheep models of Batten disease, a pediatric neurodegenerative disease. © 2019 Oxford University Press. All rights reserved.

引用

页码：44 / 51

页数：8

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