Tooth-pulp-evoked rostral spinal trigeminal neuronal excitation is attenuated by the activation of 5-HT3 receptors via GABAergic interneurons in the rat

被引：7

作者：

Oshima, Katsuo

Takeda, Mamoru

Tanimoto, Takeshi

Katsuumi, Ichiroh

Matsumoto, Shigeji

机构：

[1] Nippn Dent Univ, Sch Dent, Gen Dent Univ Hosp, Chiyoda Ku, Tokyo 1028158, Japan

[2] Nippn Dent Univ, Sch Dent, Dept Physiol, Chiyoda Ku, Tokyo 1028159, Japan

[3] Nippn Dent Univ, Sch Dent, Dept Endodont & Operat Dent, Chiyoda Ku, Tokyo 1028159, Japan

来源：

BRAIN RESEARCH | 2006年 / 1109卷

关键词：

tooth-pulp; pain; trigeminal spinal nucleus oralis; 5-HT3; receptor; GABA(A) receptor;

D O I：

10.1016/j.brainres.2006.06.036

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of iontophoretic application of the 5-HT3 receptor agonist, phenylbiguanide (PBG), on the excitation of the trigeminal spinal nucleus oralis (TSNO) neurons to tooth-pulp (TP) stimulation was examined. The PBG application inhibited the TP-evoked TSNO neuronal excitation, and this inhibition was completely blocked by co-application of a GABA(A) receptor antagonist, bicuculline. The results suggest that the activation of 5-HT3 receptors elicits GABA release in the TSNO. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：70 / 73

页数：4

共 18 条

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BRAIN RESEARCH BULLETIN, 2005, 65 (01) : 31 - 40
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EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2004, 14 : S69 - S70
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[10] Stimulatory Effect of 5-hydroxytryptamine (5-HT) on Rat Capsaicin-sensitive Vagal Pulmonary Sensory Neurons via Activation of 5-HT3 Receptors
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FASEB JOURNAL, 2011, 25

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