Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review

被引：26
|
作者：
Lewis, Joseph M. [1 ,2 ]
Macpherson, Peter [2 ,3 ]
Adams, Emily R. [4 ]
Ochodo, Eleanor [5 ]
Sands, Anita [6 ]
Taegtmeyer, Miriam [2 ]
机构：
[1] Univ Liverpool, Liverpool Sch Trop Med, Wellcome Trust Trop Ctr, Liverpool L3 5QA, Merseyside, England
[2] Univ Liverpool, Liverpool Sch Trop Med, Dept Clin Sci, Liverpool L3 5QA, Merseyside, England
[3] Univ Liverpool, Dept Publ Hlth & Policy, Liverpool L3 5QA, Merseyside, England
[4] Univ Liverpool, Liverpool Sch Trop Med, Dept Parasitol, Liverpool L3 5QA, Merseyside, England
[5] Univ Stellenbosch, Fac Med & Hlth Sci, Ctr Evidence Based Healthcare, Cape Town, South Africa
[6] WHO, Dept Essential Med & Hlth Prod, CH-1211 Geneva, Switzerland
来源：
AIDS | 2015年 / 29卷 / 18期
基金：
英国惠康基金;
关键词：
acute infection; diagnostic accuracy; HIV; point-of-care testing; rapid diagnostic tests; systematic review; CARE; INFECTION; PERFORMANCE; POINT; EXPERIENCE; ANTIGEN; BLOOD; ASSAY; TOOL;
D O I：
10.1097/QAD.0000000000000855
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Introduction:Fourth-generation HIV-1 rapid diagnostic tests (RDTs) detect HIV-1 p24 antigen to screen for acute HIV-1. However, diagnostic accuracy during clinical use may be suboptimal.Methods:Clinical sensitivity and specificity of fourth-generation RDTs for acute HIV-1 were collated from field evaluation studies in adults identified by a systematic literature search.Results:Four studies with 17381 participants from Australia, Swaziland, the United Kingdom and Malawi were identified. All reported 0% sensitivity of the HIV-1 p24 component for acute HIV-1 diagnosis; 26 acute infections were missed. Specificity ranged from 98.3 to 99.9%.Conclusion:Fourth-generation RDTs are currently unsuitable for the detection of acute HIV-1.
引用
收藏
页码：2465 / 2471
页数：7
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