The therapeutic application of mesenchymal stem cells at the ocular surface

被引：27
|
作者：
Sahu, Anuradha [1 ]
Foulsham, William [1 ,2 ]
Amouzegar, Afsaneh [1 ]
Mittal, Sharad K. [1 ]
Chauhan, Sunil K. [1 ]
机构：
[1] Harvard Med Sch, Massachusetts Eye & Ear, Schepens Eye Res Inst, Boston, MA 02114 USA
[2] UCL, Inst Ophthalmol, London, England
来源：
OCULAR SURFACE | 2019年 / 17卷 / 02期
基金：
美国国家卫生研究院;
关键词：
MARROW STROMAL CELLS; VERSUS-HOST-DISEASE; T-CELL; IN-VITRO; LYMPHOCYTE-PROLIFERATION; ALLERGIC CONJUNCTIVITIS; MYOCARDIAL-INFARCTION; STEM/STROMAL CELLS; CORNEAL EPITHELIUM; PROGENITOR CELLS;
D O I：
10.1016/j.jtos.2019.01.006
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The therapeutic potential of mesenchymal stem cells (MSCs) has been heralded by their multipotentiality and immunomodulatory capacity. MSCs migrate toward sites of tissue damage, where specific pro-inflammatory factors 'license' their immunosuppressive functions. Recent studies in animal models of ocular surface disease have demonstrated the potential of MSC-derived therapies to limit inflammation and promote tissue repair. Herein, we review the immunoregulatory mechanisms of MSCs, as well as strategies to harness their regenerative function at the cornea. We examine reports of the therapeutic application of MSCs in the setting of ocular surface inflammation; including corneal injury, transplantation, ocular surface autoimmunity and allergy.
引用
收藏
页码：198 / 207
页数：10
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