Capture of Reactive Monophosphine-Ligated Palladium(0) Intermediates by Mass Spectrometry

被引：57

作者：

Zheng, Quling ^{[1
]}

Liu, Yong ^{[2
,3
]}

Chen, Qinghao ^{[2
,3
]}

Hu, Meihong ^{[1
]}

Helmy, Roy ^{[2
,3
]}

Sherer, Edward C. ^{[2
,3
]}

Welch, Christopher J. ^{[2
,3
]}

Chen, Hao ^{[1
]}

机构：

[1] Ohio Univ, Edison Biotechnol Inst, Dept Chem & Biochem, Ctr Intelligent Chem Instrumentat, Athens, OH 45701 USA

[2] Merck & Co Inc, Dept Proc & Analyt Chem, Rahway, NJ 07065 USA

[3] Merck & Co Inc, Merck Res Labs, Dept Struct Chem, Rahway, NJ 07065 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 44期

基金：

美国国家科学基金会;

关键词：

DESORPTION ELECTROSPRAY-IONIZATION; CROSS-COUPLING REACTIONS; CATION-PI INTERACTIONS; GAS-PHASE SYNTHESIS; OXIDATIVE ADDITION; ARYL CHLORIDES; C-C; HETEROARYL CHLORIDES; COMPLEXES; CATALYSTS;

D O I：

10.1021/jacs.5b08905

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A long-sought-after reactive monophosphine-ligated palladium(0) intermediate, (PdL)-L-0 (L = phosphine ligand), was detected for the first time from the activation of the Buchwald precatalyst with base. The detection was enabled using desorption electrospray ionization mass spectrometry (DESI-MS) in combination with online reaction monitoring. The subsequent oxidative addition of (PdL)-L-0 with aryl halide and C-N coupling with amine via reductive elimination was also probed using DESI-MS.

引用

页码：14035 / 14038

页数：4

共 38 条

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