Association study of the ubiquilin gene with Alzheimer's disease

被引：26
|
作者：
Bensemain, Faiza
Chapuis, Julien
Tian, Jinzhou
Shi, Jing
Thaker, Uma
Lendon, Corinne
Iwatsubo, Takeshi
Amouyel, Philippe
Mann, David
Lambert, Jean-Charles
机构：
[1] Univ Lille 2, Inst Pasteur Lille, INSERM, U744, F-5019 Lille, France
[2] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Care Elderly, Beijing 100700, Peoples R China
[3] Hope Hosp, Greater Manchester Neurosci Ctr, Clin Neurosci Res Grp, Salford M6 8HD, Lancs, England
[4] Univ Birmingham, Queen Elizabeth Psychiat Hosp, Div Neurosci, Dept Mol Psychiat, Birmingham B15 2QZ, W Midlands, England
[5] Univ Tokyo, Dept Neuropathol & Neurosci, Tokyo 113, Japan
来源：
NEUROBIOLOGY OF DISEASE | 2006年 / 22卷 / 03期
关键词：
Alzheimer; ubiquilin; polymorphism; genetic determinant; splicing;
D O I：
10.1016/j.nbd.2006.01.007
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recently, the ubiquilin 1 gene has been proposed as a major candidate gene for AD. Here, we have investigated the potential impact of the UBQ-8i polymorphism (rs12344615) within this gene on the risk of developing AD. No association of this polymorphism with the disease was observed in a large French case-control population. Furthermore, no relationship between this polymorphism and A load or degree of neurofibrillary degeneration in the brains of 114 patients with AD was detected. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：691 / 693
页数：3
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