Genetic and molecular coordinates of neuroendocrine lung tumors, with emphasis on small-cell lung carcinomas

被引：5
|
作者：
Koutsami, MK
Doussis-Anagnostopoulou, I
Papavassiliou, AG
Gorgoulis, VG
机构：
[1] Univ Athens, Sch Med, Dept Histol & Embryol, GR-11527 Athens, Greece
[2] Univ Patras, Sch Med, Dept Biochem, GR-26110 Patras, Greece
来源：
MOLECULAR MEDICINE | 2002年 / 8卷 / 08期
关键词：
D O I：
10.1007/BF03402022
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aim of this review is to present the advances in our understanding of the progression of tumorigenesis in neuroendocrine lung tumors. Current information on established and putative diagnostic and prognostic markers of neuroendocrine tumors are evaluated, with a special reference to small-cell lung carcinoma, due to its higher incidence and aggressive behavior. The genetic and molecular changes that accompany these neoplasms are highlighted, and factors that influence cell-cycle progression, apoptosis, drug resistance, and escape from immune surveillance are critically assessed.
引用
收藏
页码：419 / 436
页数：18
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