Nonaqueous capillary electrophoretic separation of basic enantiomers using heptakis(2,3-dimethyl-6-sulfato)-β-cyclodextrin

被引：0

作者：

Tacker, M ^{[1
]}

Glukhovskiy, P ^{[1
]}

Cai, H ^{[1
]}

Vigh, G ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA

来源：

ELECTROPHORESIS | 1999年 / 20卷 / 13期

关键词：

nonaqueous capillary electrophoresis; enantiomer separations; single-isomer sulfated cyclodextrin; heptakis(2,3-dimethyl-6-sulfato)-beta-cyclodextrin methanol background electrolyte;

D O I：

10.1002/(SICI)1522-2683(19990901)20:13<2794::AID-ELPS2794>3.3.CO;2-W

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The enantiomers of 40 basic analytes, mostly pharmaceuticals, were separated by nonaqueous capillary electrophoresis in acidic methanol background electrolytes using the sodium salt of heptakis(2,3-dimethyl-6-sulfato)-beta-cyclodextrin (HDMS-beta-CD). The effective mobilities, separation selectivities, and peak resolution values were determined as a function of the HDMS-beta-CD concentration in the 0-40 mM range and were found to follow the theoretical predictions of the charged resolving agent migration model (CHARM model). Fast, efficient enantiomer separations were achieved for a large number of both very hydrophobic and hydrophilic weak bases.

引用

页码：2794 / 2798

页数：5

共 50 条

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