Interferon-stimulated genes: roles in viral pathogenesis

被引：231
|
作者：
Schoggins, John W. [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA
来源：
CURRENT OPINION IN VIROLOGY | 2014年 / 6卷
关键词：
WEST-NILE-VIRUS; HEPATITIS-C VIRUS; PROMYELOCYTIC LEUKEMIA PROTEIN; ALTERNATIVE ANTIVIRAL PATHWAYS; VESICULAR STOMATITIS-VIRUS; RNASE-L; INNATE IMMUNITY; ALPHAVIRUS REPLICATION; TARGETED DISRUPTION; DEFICIENT MICE;
D O I：
10.1016/j.coviro.2014.03.006
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Interferon-stimulated genes (ISGs) are critical for controlling virus infections. As new antiviral ISGs continue to be identified and characterized, their roles in viral pathogenesis are also being explored in more detail. Our current understanding of how ISGs impact viral pathogenesis comes largely from studies in knockout mice, with isolated examples from human clinical data. This review outlines recent developments on the contributions of various ISGs to viral disease outcomes in vivo.
引用
收藏
页码：40 / 46
页数：7
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