Association between congenital heart disease and NKX2.5 gene polymorphisms: systematic review and meta-analysis

被引：3

作者：

Gonzalez-Castro, Thelma B. ^{[1
]}

Tovilla-Zarate, Carlos A. ^{[2
]}

Lopez-Narvaez, Maria L. ^{[3
]}

Juarez-Rojop, Isela E. ^{[4
]}

Calderon-Colmenero, Juan ^{[5
]}

Sandoval, Juan P. ^{[6
]}

Garcia-Montes, Jose A. ^{[6
]}

Blachman-Braun, Ruben ^{[7
]}

Castillo-Avila, Rosa G. ^{[4
,8
]}

Garcia-Flores, Esbeidy ^{[8
]}

Cazarin-Santos, Benny G. ^{[8
]}

Borgonio-Cuadra, Veronica M. ^{[9
]}

Posadas-Sanchez, Rosalinda ^{[10
]}

Vargas-Alarcon, Gilberto ^{[8
]}

Rodriguez-Perez, Jose M. ^{[8
]}

Perez-Hernandez, Nonanzit ^{[8
]}

机构：

[1] Univ Juarez Autonoma Tabasco, Multidisciplinary Acad Div Jalpa de Mendez, Jalpa De Mendez, Tabasco, Mexico

[2] Univ Juarez Autonoma Tabasco, Multidisciplinary Acad Div Comalcalco, Comalcalco, Tabasco, Mexico

[3] Secretaria Salud, Gen Hosp Yajalon Manuel Velasco Siles, Yajalon, Chiapas, Mexico

[4] Univ Juarez Autonoma Tabasco, Acad Div Hlth Sci, Villahermosa, Tabasco, Mexico

[5] Inst Nacl Cardiol Ignacio Chavez, Dept Pediat Cardiol, Mexico City, DF, Mexico

[6] Inst Nacl Cardiol Ignacio Chavez, Lab Hemodynam & Intervent Congenital Heart Dis, Mexico City, DF, Mexico

[7] Univ Miller Sch Med, Dept Urol, Miami, FL 33136 USA

[8] Inst Nacl Cardiol Ignacio Chavez, Dept Mol Biol, Mexico City, DF, Mexico

[9] Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Dept Genet, Mexico City, DF, Mexico

[10] Inst Nacl Cardiol Ignacio Chavez, Dept Endocrinol, Mexico City, DF, Mexico

来源：

BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 18期

关键词：

congenital heart disease; meta-analysis; systematic review; NKX2; 5; gene; ATRIAL SEPTAL-DEFECT; MUTATION;

D O I：

10.2217/bmm-2020-0190

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: To analyze the association of NKX2.5 gene with congenital heart disease (CHD), and to determine if the variants rs703752, rs3729753 and rs2277923 increase the risk for developing CHD. Materials & methods: PubMed, EBSCO and Web of Science databases were screened to identify eligible studies. Through a comprehensive meta-analysis software, the association between NKX2.5 gene variants and susceptibility of CHD was calculated by pooled odd ratio (ORs) and 95% CI. Results: We observed that the allelic model of rs703752 and rs2277923 increased the risk in the overall population: OR = 1.24; 95% CI: 1.00-1.55; Z p-value = 0.049; OR = 1.18; 95% CI: 0.01-1.37; Z p-value = 0.036; respectively. Conclusion: Our results suggested that the rs703752 and rs2277923 polymorphisms of the NKX2.5 gene are associated with CHD.

引用

页码：1747 / 1757

页数：11

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