Urinary angiotensinogen in pediatric urinary tract infection

被引：4

作者：

Mayumi, Reina ^{[1
]}

Murano, Yayoi ^{[1
,2
]}

Yokota, Reina ^{[1
]}

Nakao, Akihiro ^{[1
]}

Miyazaki, Nao ^{[1
]}

Hara, Taichi ^{[2
]}

Mizotani, Akira ^{[2
]}

Hayashi, Kuniyoshi ^{[3
]}

Sakurai, Yumiko ^{[2
]}

Shoji, Hiromichi ^{[2
]}

Nakazawa, Tomoyuki ^{[1
]}

Shimizu, Toshiaki ^{[2
]}

机构：

[1] Toshima Hosp, Div Pediat, Tokyo, Japan

[2] Juntendo Univ, Dept Pediat, Tokyo, Japan

[3] St Lukes Int Univ, Ctr Clin Epidemiol, Tokyo, Japan

来源：

PEDIATRICS INTERNATIONAL | 2019年 / 61卷 / 07期

关键词：

angiotensinogen; renal scarring; renin-angiotensin system; urinary angiotensinogen; urinary tract infection; INTRARENAL OXIDATIVE STRESS; PRECEDENT; SYSTEM;

D O I：

10.1111/ped.13890

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background Urinary tract infection (UTI) is one of the most common diseases in children, and urinary angiotensinogen (U-AGT) is a new biomarker gathering attention in many renal diseases. U-AGT reflects intrarenal renin-angiotensin system (RAS) activity. We conducted a study to measure U-AGT in children UTI. Methods All children UTI group and a non-UTI group, and U-AGT was measured. Results Median U-AGT was higher in patients with UTI compared with patients without UTI: (0.56 ng/dL, range, 0.025-2.753 ng/dL vs 0.13 ng/dL, range, 0.008-1.697 ng/dL, respectively; P < 0.05). Conclusions U-AGT is elevated in UTI patients, and RAS activation may contribute to renal injury caused by UTI.

引用

页码：712 / 714

页数：3

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