Evaluation of a P,N-ligated iridium(I) catalyst in hydrogen isotope exchange reactions of aryl and heteroaryl compounds

被引：31
|
作者：
Valero, Megane [1 ]
Burhop, Annina [1 ]
Jess, Kristof [2 ]
Weck, Remo [1 ]
Tamm, Matthias [2 ]
Atzrodt, Jens [1 ]
Derdau, Volker [1 ]
机构：
[1] Sanofi, Isotope Chem & Metabolite Synth, Integrated Drug Discovery, R&D, Frankfurt, Germany
[2] Tech Univ Carolo Wilhelmina Braunschweig, Inst Anorgan & Analyt Chem, Braunschweig, Germany
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2018年 / 61卷 / 04期
关键词：
catalysis; deuterium; hydrogen isotope exchange; iridium; H/D-EXCHANGE; COMPLEXES; BINDING; RHODIUM; SULFONAMIDES; DEUTERATION; METABOLISM;
D O I：
10.1002/jlcr.3595
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We have developed a novel and efficient iridium-catalyzed hydrogen isotope exchange reaction method with secondary and tertiary sulfonamides at ambient temperatures. Furthermore N-oxides and phosphonamides have been successfully applied in hydrogen isotope exchange reactions with moderate to excellent deuterium introduction.
引用
收藏
页码：380 / 385
页数：6
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