Association between angiotensin-converting enzyme gene insertion/deletion polymorphism and pancreatitis risk: A meta-analysis

被引:3
|
作者
Fang, Fang [1 ]
Pan, Jian [1 ]
Xu, Lixiao [1 ]
Su, Guanghao [1 ]
Li, Gang [1 ]
Wang, Jian [1 ]
机构
[1] Soochow Univ, Childrens Hosp, Pediat Res Inst, Suzhou 215003, Peoples R China
关键词
Angiotensin-converting enzyme; polymorphism; pancreatitis; risk; meta-analysis; CHRONIC HYPOXIA; SYSTEM; ACTIVATION; EXPRESSION; RECEPTORS; GENOTYPE; DISEASE; CELLS;
D O I
10.1177/1470320314539827
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Objective: Many studies have focused on the relationship between the angiotensin-converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism and pancreatitis risk, but the results remain inconsistent. Thus, a meta-analysis was carried out to derive a more precise estimation of the association between ACE I/D polymorphism and pancreatitis risk. Methods: Relevant publications were searched in several widely used databases and seven studies from six eligible articles were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between ACE I/D polymorphism and pancreatitis risk. Results: Significant associations between ACE I/D polymorphism and pancreatitis risk were observed in both overall meta-analysis for DI versus II (OR=0.80, 95% CI=0.67-0.96) and DD + DI versus II (OR=0.83, 95% CI=0.70-0.98), and acute pancreatitis subgroup for DI versus II (OR=0.65, 95% CI=0.44-0.95). However, no significant pancreatitis risk variation was detected for all genetic models in the subgroup meta-analysis based on ethnicity. Conclusions: According to the results of our meta-analysis, the ACE I/D polymorphism probably associates with pancreatitis risk, especially acute pancreatitis risk, with the I allele acting as a risk factor.
引用
收藏
页码:820 / 826
页数:7
相关论文
共 50 条
  • [1] Association between angiotensin-converting enzyme gene insertion/deletion polymorphism and osteoarthritis: a meta-analysis
    Ai, Jinwei
    Liu, Jiangtao
    Liu, Ying
    Li, Desheng
    Hao, Xiaoting
    Pei, Bin
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 9 (10): : 19130 - +
  • [2] A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and the risk of overweight/obesity
    Mao, Song
    Huang, Songming
    JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2015, 16 (03) : 687 - 694
  • [3] Association of the angiotensin-converting enzyme gene insertion/deletion polymorphism with schizophrenia: A meta-analysis
    Zhang, Guofu
    Zhang, Feng
    Zhu, Jianzhong
    Zhang, Fuquan
    Yuan, Jianmin
    Jin, Chunhui
    Xue, Zhimin
    PSYCHIATRY RESEARCH, 2014, 220 (03) : 1169 - 1171
  • [4] Association between angiotensin-converting enzyme insertion/deletion polymorphism and migraine: a meta-analysis
    Wan, Dongjun
    Wang, Chunyu
    Zhang, Xiaofei
    Tang, Wenjing
    Chen, Min
    Dong, Zhao
    Yu, Shengyuan
    INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2016, 126 (05) : 393 - 399
  • [5] ASSOCIATION BETWEEN INSERTION/DELETION POLYMORPHISM IN ANGIOTENSIN-CONVERTING ENZYME GENE AND ALI/ARDS: A META-ANALYSIS
    Matsuda, A.
    Miyashita, M.
    Jacob, A.
    Aziz, M.
    Matsutani, T.
    Hayakawa, T.
    Yokoi, K.
    Uchida, E.
    Wang, P.
    SHOCK, 2013, 39 : 55 - 55
  • [6] Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and atrial fibrillation: a meta-analysis
    Liu, Tong
    Korantzopoulos, Panagiotis
    Xu, Gang
    Shehata, Michael
    Li, Dong
    Wang, Xunzhang
    Li, Guangping
    EUROPACE, 2011, 13 (03): : 346 - 354
  • [7] Association of angiotensin-converting enzyme insertion/deletion polymorphism with panic disorder risk: a meta-analysis
    Fang, Fang
    Pan, Jian
    Li, Yan-Hong
    Jin, Mei-Fang
    Xie, Yi
    Wang, Jian
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 9 (06): : 10971 - 10978
  • [8] Angiotensin-converting enzyme insertion/deletion gene polymorphism and lung cancer risk: A meta-analysis
    Wang, Nan
    Yang, DaFu
    Ji, Bin
    Li, JianYou
    JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2015, 16 (01) : 189 - 194
  • [9] Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with polycystic ovary syndrome: a meta-analysis
    Jia, Hongxia
    Wang, Bin
    Yu, Lili
    Jiang, Zhaoshun
    JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2013, 14 (03) : 255 - 262
  • [10] Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis
    Smiljana Ristić
    Nada Starčević Čizmarević
    Juraj Sepčić
    Miljenko Kapović
    Borut Peterlin
    Neurological Sciences, 2016, 37 : 1955 - 1959