Preimplantation genetic testing for aneuploidy: are we examining the correct outcomes?

被引：16
|
作者：
Kemper, James M. [1 ]
Wang, Rui [2 ]
Rolnik, Daniel L. [1 ,2 ]
Mol, Ben W. [1 ,2 ]
机构：
[1] Monash Hlth, Monash Womens, 246 Clayton Rd, Clayton, Vic 3168, Australia
[2] Monash Univ, Dept Obstet & Gynaecol, Clayton, Vic, Australia
来源：
HUMAN REPRODUCTION | 2020年 / 35卷 / 11期
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
PGT-A; IVF; outcomes; embryo; RCTs; cumulative outcomes; IN-VITRO FERTILIZATION; ASSISTED REPRODUCTIVE TECHNOLOGY; INTERNATIONAL GLOSSARY; FERTILITY CARE; INFERTILITY; DIAGNOSIS; RATES; TIME; PGD;
D O I：
10.1093/humrep/deaa224
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Questions continue to be raised regarding the benefit of genetic assessment of embryos prior to transfer in IVF, specifically with regards to preimplantation genetic testing for aneuploidy (PGT-A). To evaluate and quantify these concerns, we appraised the most recent (2012-2019) randomized controlled trials on the topic. Only two of these six studies listed cumulative live birth rates per started cycle, with both eliciting a statistically non-significant result. This article describes the concern that a focus on results from the first embryo transfer compared to cumulative outcomes falsely construes PGT-A as having superior outcomes, whilst its true benefit is not confirmed, and it cannot actually improve the true pregnancy outcome of an embryo pool.
引用
收藏
页码：2408 / 2412
页数：5
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