Calcium-induced long-term potentiation in horizontal connections of rat motor cortex

被引:15
|
作者
Hess, G
机构
[1] Jagiellonian Univ, Inst Zool, PL-30060 Krakow, Poland
[2] Polish Acad Sci, Inst Pharmacol, PL-31343 Krakow, Poland
关键词
synaptic plasticity; brain slice; adult rat;
D O I
10.1016/S0006-8993(02)03296-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A transient (10 min) exposure of brain slices of young adult rats to elevated extracellular calcium (5 mM) resulted in a long-lasting potentiation of field potentials evoked in layer II/III and layer V horizontal connections of the primary motor cortex. This form of synaptic plasticity was blocked by D,L-2-amino-5-phosphonovalerate (APV, 100 muM), an antagonist of NMDA receptors. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:142 / 145
页数:4
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