Comparison of fed-batch strategies in hybridoma cultures

被引：0

作者：

Schwabe, JO ^{[1
]}

Wilkens, I ^{[1
]}

Pörtner, R ^{[1
]}

机构：

[1] Tech Univ Hamburg Harburg, D-21071 Hamburg, Germany

来源：

ANIMAL CELL TECHNOLOGY: PRODUCTS FROM CELLS, CELLS AS PRODUCTS | 1999年

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The classical cell culture process in stirred tank or airlift reactors is still the mostly used large scale production system. Fed-batch processes with different feeding strategies have been investigated to improve the productivity of hybridoma cultures. The following approaches for substrate control are compared in this work: model-based control, on-line characterisation and the application of linear feed trajectories. The required knowledge and the effort for implementation is discussed.

引用

页码：167 / 169

页数：3

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