Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis

被引：124
|
作者：
Wu, Chang-Ping [1 ]
Jiang, Jing-Ting
Tan, Min
Zhu, Yi-Bei
Ji, Mei
Xu, Kuan-Feng
Zhao, Jie-Min
Zhang, Guang-Bo
Zhang, Xue-Guang
机构：
[1] Suzhou Univ, Affiliated Hosp 3, Changzhou 213003, Jiangsu Prov, Peoples R China
[2] Suzhou Univ, Inst Biotechnol, Key Lab Clin Immunol Jiangsu Prov, Suzhou 215007, Jiangsu Prov, Peoples R China
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2006年 / 12卷 / 03期
关键词：
B7-H3; expression; gastric carcinoma; gastric adenoma; prognosis;
D O I：
10.3748/wjg.v12.i3.457
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
AIM: To investigate the expression of co-stimulatory molecule B7-H3 in gastric carcinoma and adenoma tissue as well as normal gastric tissue and to explore the relationship between B7-H3 expression and pathological features and prognosis of gastric carcinoma. METHODS: B7-H3 expression was detected in 102 samples of human gastric carcinoma and 10 samples of gastric adenoma and 10 samples of normal gastric tissue by immunohistochemical assay. Correlation between the expression of B7-H3 and the patients' age, sex, gastric carcinoma locus, tumor size, tissue type, tumor infiltration depth, differentiation degree, lymph node metastasis, and survival time was analyzed. RESULTS: B7-H3 was expressed in all gastric adenoma samples and in 58.8% samples of gastric carcinoma. B7-H3 expression in gastric carcinoma samples was not related with the patients' age, sex, lymph node metastasis, and tumor size (P>0.05), but with the survival time, infiltration depth of tumor and tissue type. CONCLUSION: Detection of B7-H3 expression in gastric carcinoma tissue is beneficial to the judgment of the prognosis of gastric carcinoma patients and the choice of treatment. (C) 2006 The WJG Press. All rights reserved.
引用
收藏
页码：457 / 459
页数：3
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