The interaction between cytochrome c and trans-[PtCl2(NH3)(2)]

被引：3
|
作者：
Jiang, LJ
Tang, GZ
Tang, WX
机构：
[1] NANJING UNIV,INST COORDINAT CHEM,STATE KEY LAB COORDINAT CHEM,NANJING 210093,PEOPLES R CHINA
[2] NANJING UNIV,DEPT BIOCHEM,NANJING 210093,PEOPLES R CHINA
来源：
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1996年 / 11期
关键词：
D O I：
10.1039/dt9960002223
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The reaction between cytochrome c and trans-[PtCl2(NH3)(2)] has been studied under different conditions. The complex can not only bind to a Met-80 residue, which causes the Fe-S bond of ferricytochrome c to be broken, but can also induce a facile conversation of low-spin iron(III) cytochrome c to the high-spin form under mild conditions. Cytochrome c can also be cross-linked selectively by trans-[PtCl2(NH3)(2)]. The binding sites of the platinum complex in the protein derivatives were identified by analysis of the molar ratio of the two metals (Pt and Fe), H-1 NMR and UV/VIS spectroscopy and differential-pulse voltammetry.
引用
收藏
页码：2223 / 2226
页数：4
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