Macro and Small over Micro: Macromolecules and Small Molecules that Regulate MicroRNAs

被引：7
|
作者：
Kang, Soowon [1 ]
Im, Kyungtaek [1 ]
Baek, Jihae [1 ]
Yoon, Sungroh [2 ]
Min, Hyeyoung [1 ]
机构：
[1] Chung Ang Univ, Dept Pharm, Seoul 156756, South Korea
[2] Seoul Natl Univ, Dept Elect & Comp Engn, Seoul 151744, South Korea
来源：
CHEMBIOCHEM | 2014年 / 15卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
high-throughput screening; microRNAs; regulators; RNA; small molecules; LOCKED NUCLEIC-ACID; GENE-EXPRESSION; RNA-INTERFERENCE; DOWN-REGULATION; MIRNA; MIR-21; OLIGONUCLEOTIDES; INHIBITORS; DISCOVERY; TARGETS;
D O I：
10.1002/cbic.201402007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Given the correlation between the deregulation of specific miRNAs and disease onset, it is critical to identify miRNA regulators that effectively control miRNAs involved in the pathogenesis of target diseases. This review provides the latest update on oligonucleotide- and small-molecule-based miRNA regulators, and discusses assays developed to screen for small-molecule regulators. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1071 / 1078
页数：8
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