Can prenylcysteines be exploited as ligands for mammalian multidrug-resistance transporters?

被引：1
|
作者：
Hurwitz, LM [1 ]
Casey, PJ [1 ]
机构：
[1] DUKE UNIV,MED CTR,DEPT PHARMACOL & CANC BIOL,DURHAM,NC 27710
来源：
CHEMISTRY & BIOLOGY | 1997年 / 4卷 / 10期
关键词：
D O I：
10.1016/S1074-5521(97)90308-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The overexpression of specific transport proteins in the membrane of many cancer cells renders these cells resistant to many therapeutic drugs. Some lipid-modified cysteine compounds inhibit one drug-transporting protein, indicating the potential of developing such compounds as therapeutic agents.
引用
收藏
页码：711 / 715
页数：5
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