Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation

被引：30

作者：

Blass, Benjamin E. ^{[1
]}

Coburn, Keith ^{[1
]}

Lee, Wenlin ^{[1
]}

Fairweather, Nell ^{[1
]}

Fluxe, Andrew ^{[1
]}

Wu, Shengde ^{[1
]}

Janusz, John M. ^{[1
]}

Murawsky, Michael ^{[1
]}

Fadayel, Gina M. ^{[1
]}

Fang, Bin ^{[1
]}

Hare, Michelle ^{[1
]}

Ridgeway, Jim ^{[1
]}

White, Ron ^{[1
]}

Jackson, Chris ^{[1
]}

Djandjighian, Laurent ^{[1
]}

Hedges, Richard ^{[1
]}

Wireko, Fred C. ^{[1
]}

Ritter, Amanda L. ^{[1
]}

机构：

[1] Procter & Gamble Co, Hlth Care Res Ctr, Mason, OH 43040 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 17期

关键词：

atrial fibrillation; Kv1.5 ion channel; 1,2,3-triazole;

D O I：

10.1016/j.bmcl.2006.06.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones were prepared and examined for utility as Kv1.5 channel blockers for the treatment of atrial fibrillation. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4629 / 4632

页数：4

共 50 条

[1] N-[(2-Phenyl-2H-1,2,3-triazol-4-yl)methylene]-2-(2-(2-phenyl-2H-1,2,3-triazol-4-yl)-3-{2-[(2-phenyl-2H-1,2,3-triazol-4-yl)methyleneamino]ethyl}imidazolidin-1-yl)ethanamine
Feng, Yue
Liu, Gang
Yue, Fan
Wang, Ji-De
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 2008, 64 : O426 - O427
[2] SYNTHESIS OF SOME NEW (1-ARYL-5-METHYL-1H-1,2,3-TRIAZOL-4-YL)-(2,4-DIHYDROXY-PHENYL)-METHANONES
Jin, Chi-Qiong
Quan, Bin
Dong, Heng-Shan
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2008, 18 (02) : 199 - 200
[3] 2-[(E)-(2-Phenyl-2H-1,2,3-triazol-4-yl)methyleneamino]ethanol
Dang, Yan-Qiu
Tian, Lai-Jin
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O720 - U1706
[4] Synthesis and antifungal evaluation of (1,2,3-triazol-4-yl)methyl nicotinate chitosan
Qin, Yukun
Liu, Song
Xing, Ronge
Li, Kecheng
Yu, Huahua
Li, Pengcheng
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 61 : 58 - 62
[5] Synthesis and biological evaluation of new 4-(4-(1-benzyl-1H-1,2,3-triazol-4-yl)phenyl)-2-phenylthiazole derivatives
Shinde, Vikas
Mhaske, Pravin C.
Singh, Aakriti
Sarkar, Dhiman
Mahulikar, Pramod
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2019, 56 (11) : 3093 - 3101
[6] Synthesis and biological activity of new 2,6-diphenyl-4-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridines
Subhashini, N. J. P.
Reddy, Ch. B.
Kumar, P. A.
Lingaiah, B.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2016, 86 (12) : 2845 - 2848
[7] Synthesis and biological activity of new 2,6-diphenyl-4-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridines
N. J. P. Subhashini
Ch. B. Reddy
P. A. Kumar
B. Lingaiah
Russian Journal of General Chemistry, 2016, 86 : 2845 - 2848
[8] Synthesis and Characterization of 2-(2-((1-Aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)benzoxazoles: Evaluation of Cytotoxicity and Antioxidant Activity
Thakral, Sumit
Rani, Suman
Lal, Kashmiri
Kumar, Devinder
CHEMISTRYSELECT, 2022, 7 (43):
[9] Synthesis of (1,2,3-triazol-4-yl)methyl Phosphinates and (1,2,3-Triazol-4-yl)methyl Phosphates by Copper-Catalyzed Azide-Alkyne Cycloaddition
Tripolszky, Anna
Nemeth, Krisztina
Szabo, Pal Tamas
Balint, Erika
MOLECULES, 2019, 24 (11):
[10] (1-Phenyl-1H-1,2,3-triazol-4-yl)methyl pyridine-3-carboxylate
Karimov, Zakirjon
Abdugafurov, Ibrakhim
Talipov, Samat
Tashkhodjaev, Bakhodir
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O1674 - U311

← 1 2 3 4 5 →