Synthesis of protected α-alkyl lanthionine derivatives

被引：9

作者：

Denoel, Thibaut ^{[1
]}

Zervosen, Astrid ^{[1
]}

Lemaire, Christian ^{[1
]}

Plenevaux, Alain ^{[1
]}

Luxen, Andre ^{[1
]}

机构：

[1] Univ Liege, Cyclotron Res Ctr, B-4000 Liege, Belgium

来源：

TETRAHEDRON | 2014年 / 70卷 / 30期

关键词：

Lanthionine; Sulfamidate; alpha-Alkyl amino acid; Peptidoglycan; Protected amino acid; ALPHA; ALPHA-DISUBSTITUTED AMINO-ACID; ENANTIOSELECTIVE SYNTHESIS; EFFICIENT; CHEMISTRY;

D O I：

10.1016/j.tet.2014.05.004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Protected alpha-alkyl lanthionine derivatives were synthesized in five steps starting from a known phenyl-oxazoline precursor. This approach involved the synthesis of a family of substituted cyclic sulfamidates and their regioselective opening by nucleophilic attack with a protected cysteine. This efficient multistep strategy affords various alpha-alkylated lanthionine derivatives in high yields. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：4526 / 4533

页数：8

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