Determination of ionophore antibiotics nactins produced by fecal Streptomyces from sheep

被引：4
|
作者：
Wang, Jun [1 ]
Tan, Hongming [2 ]
Lu, Yu [1 ]
Cao, Lixiang [2 ]
机构：
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China
来源：
BIOMETALS | 2014年 / 27卷 / 02期
关键词：
Ionophores; Nactins; Ruminant; Streptomyces; ANIMAL FEED; RESISTANCE; NONACTIN;
D O I：
10.1007/s10534-014-9709-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To investigate the correlation between fecal actinobacteria and host animals, Streptomyces was isolated from fresh faeces of healthy sheep and secondary metabolites were analyzed. The most frequently isolated strain S161 with antibiotic activity against bacteria and fungi were analyzed. The S161 showed the highest 99 % similarity to Streptomyces canus DSB17 based on the 16S rRNA gene sequence analysis. Metabolite analysis based on MS and NMR spectra showed that S161 produces nactins, cyclotetralactones derived from nonactic acid and homononactic acid as building units of ionophoretic character. Due to ionophores are antimicrobial compounds that are commonly fed to ruminant animals to improve feed efficiency, stable beneficial interactions between Streptomyces bacteria and vertebrates have been demonstrated.
引用
收藏
页码：403 / 407
页数：5
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