Screening of differentially expressed genes in pathological scar tissues using expression microarray

被引：3
|
作者：
Huang, L. P. [1 ]
Mao, Z. [2 ]
Zhang, L. [3 ]
Liu, X. X. [1 ]
Huang, C.
Jia, Z. S. [1 ]
机构：
[1] Chinese Peoples Liberat Army Gen Hosp, Dept Phys Therapy, Beijing 100853, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China
[3] Dalian City Hosp Tradit Chinese Med, Dalian, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2015年 / 14卷 / 03期
关键词：
Pathological scar tissue; Differentially expressed gene; Gene chip;
D O I：
10.4238/2015.September.9.13
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pathological scar tissues and normal skin tissues were differentiated by screening for differentially expressed genes in pathologic scar tissues via gene expression microarray. The differentially expressed gene data was analyzed by gene ontology and pathway analyses. There were 5001 up-or down-regulated genes in 2-fold differentially expressed genes, 956 up-or down-regulated genes in 5-fold differentially expressed genes, and 114 up- or down-regulated genes in 20-fold differentially expressed genes. Therefore, significant differences were observed in the gene expression in pathological scar tissues and normal foreskin tissues. The development of pathological scar tissues has been correlated to changes in multiple genes and pathways, which are believed to form a dynamic network connection.
引用
收藏
页码：10743 / 10751
页数：9
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