A self-assembling β-peptide hydrogel for neural tissue engineering

被引:71
|
作者
Motamed, S. [1 ]
Del Borgo, M. P. [2 ,3 ]
Kulkarni, K. [4 ]
Habila, N. [2 ,3 ]
Zhou, K. [1 ]
Perlmutter, P. [4 ]
Forsythe, J. S. [1 ]
Aguilar, M. I. [2 ,3 ]
机构
[1] Monash Univ, Monash Inst Med Engn, Dept Mat Sci & Engn, Clayton, Vic 3800, Australia
[2] Monash Univ, Monash Biomed Discovery Inst, Clayton, Vic 3800, Australia
[3] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia
[4] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia
关键词
AMINO-ACID; IN-VITRO; PROTEOLYTIC STABILITY; NEURITE OUTGROWTH; SCAFFOLD; BIOMATERIALS; NANOFIBERS; DESIGN; REPAIR; NANO;
D O I
10.1039/c5sm02902c
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
We report a new class of beta-peptide based hydrogel for neural tissue engineering. Our beta-peptide forms a network of nanofibres in aqueous solution, resulting in a stable hydrogel at physiological conditions. The hydrogel shows excellent compatibility with neural cells and provides a suitable environment for cells to adhere and proliferate.
引用
收藏
页码:2243 / 2246
页数:4
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