A high-resolution comparative radiation hybrid map of equine chromosome 4q12-q22

被引：9
|
作者：
Dierks, C.
Momke, S.
Drogemuller, C.
Leeb, T.
Chowdhary, B. P.
Distl, O.
机构：
[1] Univ Vet Med Hannover, Inst Anim Breeding & Genet, D-30559 Hannover, Germany
[2] Texas A&M Univ, Coll Vet Med, Dept Vet Anat & Publ Hlth, College Stn, TX 77843 USA
来源：
ANIMAL GENETICS | 2006年 / 37卷 / 05期
关键词：
comparative map; equine chromosome 4; Equus caballus; fluorescent in situ hybridization; radiation hybrid mapping;
D O I：
10.1111/j.1365-2052.2006.01510.x
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
In this study, we present a comprehensive 5000-rad radiation hybrid map of a 40-cM region on equine chromosome 4 (ECA4) that contains quantitative trait loci for equine osteochondrosis. We mapped 29 gene-associated sequence tagged site markers using primers designed from equine expressed sequence tags or BAC clones in the ECA4q12-q22 region. Three blocks of conserved synteny, showing two chromosomal breakpoints, were identified in the segment of ECA4q12-q22. Markers from other segments of HSA7q mapped to ECA13p and ECA4p, and a region of HSA7p was homologous to ECA13p. Therefore, we have improved the resolution of the human-equine comparative map, which allows the identification of candidate genes underlying traits of interest.
引用
收藏
页码：513 / 517
页数：5
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