A Belgian consensus protocol for autologous hematopoietic stem cell transplantation in multiple sclerosis

被引：3

作者：

Laureys, Guy ^{[1
]}

Willekens, Barbara ^{[2
]}

Vanopdenbosch, Ludo ^{[3
]}

Deryck, Olivier ^{[3
]}

Selleslag, Dominik ^{[4
]}

D'Haeseleer, Miguel ^{[5
]}

De Becker, Ann ^{[6
]}

Dubois, Benedicte ^{[7
]}

Dierickx, Daan ^{[8
]}

Perrotta, Gaetano ^{[9
]}

De Wilde, Virginie ^{[10
]}

van Pesch, Vincent ^{[11
]}

Straetmans, Nicole ^{[12
]}

Dive, Dominique ^{[13
]}

Beguin, Yves ^{[14
]}

Van Wijmeersch, Bart ^{[15
,16
]}

Theunissen, Koen ^{[17
]}

Kerre, Tessa ^{[18
]}

Van de Velde, Ann ^{[19
]}

机构：

[1] Ghent Univ Hosp, Dept Neurol, De Pintelaan 185, B-9000 Ghent, Belgium

[2] Antwerp Univ Hosp, Dept Neurol, Wilrijkstr 10, B-2650 Edegem, Belgium

[3] AZ Sint Jan Brugge Oostende, Dept Neurol, Ruddershove 10, B-8000 Brugge, Belgium

[4] AZ Sint Jan Brugge Oostende, Dept Hematol, Ruddershove 10, B-8000 Brugge, Belgium

[5] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Ctr Neurosci, Dept Neurol, Brussels, Belgium

[6] UZ Brussel, Dept Hematol, Laarbeeklaan 101, B-1090 Brussels, Belgium

[7] UZ Leuven, Dept Neurol, Herestr 49, B-3000 Louvain, Belgium

[8] UZ Leuven, Dept Hematol, Herestr 49, B-3000 Louvain, Belgium

[9] Univ Libre Bruxelles, Hop Erasme, Serv Neurol, Unite Neuroimmunol, Brussels, Belgium

[10] Univ Libre Bruxelles, Hop Erasme, Dept Hematol, Brussels, Belgium

[11] Catholic Univ Louvain, Clin Univ St Luc, Dept Neurol, Ave Hippocrate 10, B-1200 Brussels, Belgium

[12] Catholic Univ Louvain, Clin Univ St Luc, Dept Hematol, Ave Hippocrate 10, B-1200 Brussels, Belgium

[13] Univ Hosp Liege, Dept Neurol, Rue Grandfosse 31-33, B-4130 Esneux, Belgium

[14] Univ Liege, CHU Sart Tilman, Dept Hematol, B-4000 Liege, Belgium

[15] Hasselt Univ, Biomed Inst, Agoralaan Gebouw A, B-3590 Diepenbeek, Belgium

[16] Rehabil & MS Ctr Overpelt, Agoralaan Gebouw A, B-3590 Diepenbeek, Belgium

[17] Jessa Ziekenhuis, Dept Hematol, Stadsomvaart 11, B-3500 Hasselt, Belgium

[18] Ghent Univ Hosp, Dept Hematol, De Pintelaan 185, B-9000 Ghent, Belgium

[19] Antwerp Univ Hosp, Dept Hematol, Wilrijkstr 10, B-2650 Edegem, Belgium

来源：

ACTA NEUROLOGICA BELGICA | 2018年 / 118卷 / 02期

关键词：

Multiple sclerosis; Autologous hematopoietic stem cell transplantation; Consensus Paper; DISEASE-ACTIVITY; CLINICAL-COURSE; MS; GUIDELINES; EXPERIENCE; TRIAL; NEDA; MRI;

D O I：

10.1007/s13760-018-0905-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis is considered to be an immune mediated inflammatory disorder of the central nervous system. It mainly affects young, socioeconomic active patients. Although our armamentarium for this disease has significantly evolved in recent years some patients remain refractory to conventional therapies. In these cases, autologous hematopoietic stem cell transplantation can be considered as a therapeutic option. Decreasing morbidity, mortality, and increasing patient awareness have led to rising inquiry by our patients about this treatment option. With the aim of a standardized protocol and data registration, a Belgian working party on stem cell therapy in multiple sclerosis was established. In this paper, we report the consensus protocol of this working party on autologous hematopoietic stem cell transplantation in multiple sclerosis.

引用

页码：161 / 168

页数：8

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