Efficacy of Intrathecal Morphine Combined with Intravenous Analgesia versus Thoracic Epidural Analgesia after Gastrectomy

被引:11
|
作者
Lee, Jae Hoon [1 ]
Park, Jin Ha [1 ]
Kil, Hae Keum [1 ]
Choi, Seung Ho [1 ]
Noh, Sung Hoon [2 ]
Koo, Bon-Nyeo [1 ]
机构
[1] Yonsei Univ, Coll Med, Dept Anesthesiol & Pain Med, Severance Hosp,Anesthesia & Pain Res Inst, Seoul 120752, South Korea
[2] Yonsei Univ, Coll Med, Dept Surg, Severance Hosp, Seoul 120752, South Korea
关键词
Analgesia; epidural; gastrectomy; intrathecal; opioid; postoperative pain; LAPAROSCOPIC COLORECTAL SURGERY; PATIENT-CONTROLLED ANALGESIA; POSTOPERATIVE ANALGESIA; RANDOMIZED-TRIALS; CLINICAL-TRIAL; MAJOR SURGERY; PCA MORPHINE; PLUS PCA; PAIN; ANESTHESIA;
D O I
10.3349/ymj.2014.55.4.1106
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose: Epidural analgesia has been the preferred analgesic technique after major abdominal surgery. On the other hand, the combined use of intrathecal morphine (ITM) and intravenous patient controlled analgesia (IVPCA) has been shown to be a viable alternative approach for analgesia. We hypothesized that ITM combined with IVPCA is as effective as patient controlled thoracic epidural analgesia (PC-TEA) with respect to postoperative pain control after conventional open gastrectomy. Materials and Methods: Sixty-four patients undergoing conventional open gastrectomy due to gastric cancer were randomly allocated into the intrathecal morphine combined with intravenous patient-controlled analgesia (IT) group or patient-controlled thoracic epidural analgesia (EP) group. The IT group received preoperative 0.3 mg of ITM, followed by postoperative IVPCA. The EP group preoperatively underwent epidural catheterization, followed by postoperative PC LEA. Visual analog scale (VAS) scores were assessed until 48 hrs after surgery Adverse effects related to analgesia, profiles associated with recovery from surgery, and postoperative complications within 30 days after surgery were also evaluated. Results: This study failed to demonstrate the non-inferiority of ITM-IVPCA (n=29) to PCTEA (n=30) with respect to VAS 24 hrs after surgery. Furthermore, the IT group consumed more fentanyl than the EP group did (1247.1 +/- 263.7 mu g vs. 1048.9 +/- 71.7 mu g, p<0.001). The IT group took a longer time to ambulate than the EP group (p=0.021) and had higher incidences of postoperative ileus (p=0.012) and pulmonary complications (p=0.05) compared with the EP group. Conclusion: ITM-IVPCA is not as effective as PCTEA in patients undergoing gastrectomy, with respect to pain control, ambulation, postoperative ileus and pulmonary complications.
引用
收藏
页码:1106 / 1114
页数:9
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