Translational strategies and challenges in regenerative medicine

被引：129

作者：

Dimmeler, Stefanie ^{[1
]}

Ding, Sheng ^{[2
]}

Rando, Thomas A. ^{[3
,4
]}

Trounson, Alan ^{[5
]}

机构：

[1] Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, Frankfurt, Germany

[2] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA USA

[3] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA USA

[4] Stanford Univ, Glenn Ctr Biol Aging, Stanford, CA USA

[5] Calif Inst Regenerat Med CIRM, San Francisco, CA USA

来源：

NATURE MEDICINE | 2014年 / 20卷 / 08期

关键词：

HEMATOPOIETIC STEM-CELL; PROGENITOR CELLS; MOUSE FIBROBLASTS; MONONUCLEAR-CELLS; SENESCENT CELLS; REJUVENATION; MATRIX; BIODISTRIBUTION; TUMORIGENICITY; CARDIOMYOCYTES;

D O I：

10.1038/nm.3627

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The scientific community is currently witnessing substantial strides in understanding stem cell biology in humans; however, major disappointments in translating this knowledge into medical therapies are flooding the field as well.Despite these setbacks, investigators are determined to better understand the caveats of regeneration, so that major pathways of repair and regrowth can be exploited in treating aged and diseased tissues. Last year, in an effort to contribute to this burgeoning field,Nature Medicine, in collaboration with the Volkswagen Foundation, organizeda meeting with a panel of experts in regenerative medicine to identify the most pressing challenges, as well as the crucial strategies and stem cell concepts that can best help advance the translational regenerative field. Here some experts who participated in the meeting provide an outlook at some of those key issues and concepts.

引用

页码：814 / 821

页数：8

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