Synthesis of 5-[4,5-13C2]- and 5-[1,5-13C2]aminolevulinic acid

被引：11

作者：

Iida, K ^{[1
]}

Tokiwa, S ^{[1
]}

Ishii, T ^{[1
]}

Kajiwara, M ^{[1
]}

机构：

[1] Meiji Pharmaceut Univ, Dept Med Chem, Tokyo 2048588, Japan

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2002年 / 45卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

5-[4,5-C-13(2)]aminolevulinic acid; 5-[1,5-C-13(2)]aminolevulinic acid; 1,2-C-13(2)]acetic acid; sodium [2-C-13]acetate; potassium [C-13]cyanide;

D O I：

10.1002/jlcr.583

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

5-[4,5-C-13(2)]- and 5-[1,5-C-13(2)]Aminolevulinic acid (ALA) have been synthesized by the Gabriel condensation of potassium phthalimide with ethyl bromo [1,2-C-13(2)]acetate (derived from [1,2-C-13-]acetic acid) or ethyl bromo[2-C-13]- acetate (derived from sodium [2-C-13]acetate), followed by conversion to the chloride, coupling reaction with 2-ethoxycarbonylethylzinc iodide derived from ethyl 3-iodopropionate or 2-methoxy[C-13]carbonylethylzinc iodide derived from methyl 3-iodo[1-C-13]propionate (generated from potassium [C-13]cyanide), and hydrolysis. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：569 / 576

页数：8

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