Luminescent Molecular Octopuses with a Polyhedral Oligomeric Silsesquioxane (POSS) Core and Iridium(III) Polypyridine Arms: Synthesis, Aggregation Induced Emission, Cellular Uptake, and Bioimaging Studies

被引：19

作者：

Zhu, Jing-Hui ^{[1
]}

Tang, Ben Zhong ^{[2
]}

Lo, Kenneth Kam-Wing ^{[1
,3
,4
]}

机构：

[1] City Univ Hong Kong, Dept Chem, Tat Chee Ave, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Dept Chem, Clear Water Bay, Kowloon, Hong Kong, Peoples R China

[3] City Univ Hong Kong, State Key Lab Terahertz & Millimeter Waves, Tat Chee Ave, Hong Kong, Peoples R China

[4] City Univ Hong Kong, Ctr Funct Photon, Tat Chee Ave, Hong Kong, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2019年 / 25卷 / 45期

基金：

中国国家自然科学基金;

关键词：

aggregation; imaging agents; iridium; luminescence; silsesquioxanes; CYCLOMETALATED IRIDIUM(III); COMPLEXES; NANOPARTICLES; PROBES; FLUORESCENCE; DELIVERY; DESIGN; RUTHENIUM(II); ENDOCYTOSIS; RHENIUM(I);

D O I：

10.1002/chem.201901029

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new class of luminescent molecular hybrids in which eight cyclometalated iridium(III) polypyridine complexes are grafted onto a polyhedral oligomeric silsesquioxane (POSS) unit [POSS-{Ir(N<^>C)(2)(py-im)}(8)](PF6)(8) [py-im=pyridine imine; HN<^>C=N-phenylpyrazole (Hppz) (1 a), 2-phenylpyridine (Hppy) (2 a), 2-phenylquinoline (Hpq) (3 a)] were synthesized and characterized. On photoexcitation, the complexes showed intense and long-lived orange-red to red emission in fluid solutions at room temperature and in low-temperature glasses. The photophysical properties including aggregation-induced emission and biological properties of these complexes were studied and compared with those of their POSS-free counterparts [Ir(N<^>C)(2)(py-im)](PF6) [HN<^>C=Hppz (1 b), Hppy (2 b), Hpq (3 b)]. The (photo)cytotoxicity of the complexes was examined by the MTT assay, and their cellular uptake and intracellular localization were investigated by inductively coupled plasma-mass spectrometry and laser-scanning confocal microscopy.

引用

页码：10633 / 10641

页数：9