Polygenic score development in the era of large-scale biobanks

被引：0
|
作者：
Plagnol, Vincent [1 ]
机构：
[1] Genomics Plc, King Charles House,Pk End St, Oxford OX1 1JD, England
来源：
CELL GENOMICS | 2022年 / 2卷 / 01期
关键词：
D O I：
10.1016/j.xgen.2021.100088
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In this issue of Cell Genomics, Xu et al. report a comprehensive analysis of the genetics of 26 blood cell traits, leveraging data from two large biobanks to construct and make available machine-learning optimized polygenic scores (PGSs). In addition to delivering insights into the biology and clinical associations of these traits, the authors evaluate and provide recommendations on methods for PGS construction.
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页数：3
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